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How the treatment process works

Learning how to tolerate small amounts of peanut protein with no more than mild symptoms takes time. Slowly consuming more and more of an allergen over a long period of time is part of a process called oral immunotherapy, or OIT. Treatment with PALFORZIA starts with a build-up process that takes place over the course of about 6 months with increasing dose levels and then continues with a daily Maintenance Dose.

Smiling girl

Getting ready for your child’s first treatment

Your child’s first dosing appointment is called the Initial Dose Escalation (IDE) visit. The IDE will take at least 4 hours, so it is a good idea to plan ahead. 

What HAPPENS

  • 1

    Check in

    Your child's allergist will discuss the treatment process, review the Medication Guide, take your child’s vital signs, and confirm that your child is enrolled in the REMS program for PALFORZIA.

  • 2

    First dose and observation

    Your child's allergist will give your child the first dose of PALFORZIA and wait 20–30 minutes to evaluate any potential allergic reactions and determine how to proceed.

  • 3

    Dose escalation and observation

    There will be four more doses, for a total of five. After each dose, you will wait 20–30 minutes to make sure doses can continue. However, after the final dose your child's allergist will observe your child for 60 minutes.

    Should an allergic reaction occur, your allergist will treat it accordingly, which may also include discontinuing PALFORZIA.

What to bring

Here is a list of items you may want to bring to the IDE appointment. Check with your child's allergist to make sure you have everything that their office might require as well.

Insurance card iconMedication list iconInjectable epinephrine icon
  • Insurance card
  • List of other medications your child may be taking
  • Injectable epinephrine
Book iconParent and child icon
  • Books, games, toys, etc.
  • Make a plan with your child, and bring activities that will keep you both entertained

Continuing treatment at home

Once your child has completed the Initial Dose Escalation visit, bring your child back to the allergist’s office, preferably the next day, for initiation of Up-Dosing at a 3 mg dose. The Up-Dosing phase typically lasts six months, with an initial visit to the doctor’s office during each dosage increase, followed by two weeks of daily at-home dosing treatment.

Your child’s safety is our highest priority, so we put together this list of “Do’s and Don’ts” to help you establish your home treatment routine in the safest possible way.

For detailed information about how to prepare and administer PALFORZIA at home, be sure to talk to your child’s allergist or refer to the Treatment Handbook for detailed dosing guidance.

  • Yes icon
    Continue to have your child carry their injectable epinephrine.
  • Yes icon
    Have your child take their dose of PALFORZIA with a meal at the same time every day; mix it well into a few spoonfuls of a soft food, such as applesauce, yogurt, or pudding, that’s either cold or at room temperature (not hot and not liquid). Talk to your child's allergist if you have any questions.
  • Yes icon
    Keep an eye on your child for one hour after they take their dose, in case there are any signs of an allergic reaction.
  • Yes icon
    Keep PALFORZIA in the refrigerator.
  • Yes icon
    If your child misses taking PALFORZIA, contact your child's allergist. Do not take additional doses on the same day to make up for missed doses.
  • Yes icon
    Be aware of certain conditions that may increase the likelihood of an allergic reaction, including having an illness such as a viral infection, being very tired or missing sleep, being stressed, having a menstrual period, exercising, taking certain pain medications such as aspirin or ibuprofen, or drinking alcohol.
  • No icon
    Do not have your child eat peanuts or peanut products as part of their diet.
  • No icon
    Do not give your child their daily dose of PALFORZIA on the day of an appointment, since they will be receiving some from your child's allergist.
  • No icon
    Do not take more than one dose of PALFORZIA in a single day.
  • No icon
    Do not give any more doses if your child has missed a dose of PALFORZIA. Instead, contact your child's allergist for next steps in continuing treatment.
  • No icon
    Do not let your child swallow the capsule or inhale 
the powder.
  • No icon
    Do not give your child PALFORZIA if they are very hot or have just participated in any strenuous physical activity, like a game or sport, and still have a high 
heart rate.
  • No icon
    Do not let your child participate in sports or other strenuous physical activity or take a hot bath or shower within three hours after taking PALFORZIA.

Need more information? 

Download our Treatment Handbook for more details on the treatment process. We also have a secondary caregivers guide you can share with teachers, babysitters, family members, and anyone else who may need to know about peanut allergy treatment. 

IMPORTANT SAFETY INFORMATION

PALFORZIA can cause severe allergic reactions called anaphylaxis that may be life-threatening.

  • You will receive your first dose in a healthcare setting under the observation of trained healthcare staff.

  • You will receive the first dose of all dose increases in a healthcare setting.

  • In the healthcare setting, you will be observed for at least 1 hour for signs and symptoms of a severe allergic reaction.

  • If you have a severe reaction during treatment, you will need to receive an injection of epinephrine immediately and get emergency medical help right away.

  • You will return to the healthcare setting for any trouble tolerating your home doses.

Stop taking PALFORZIA and get emergency medical treatment right away if you have any of the following symptoms after taking PALFORZIA:

  • Trouble breathing or wheezing

  • Chest discomfort or tightness

  • Throat tightness

  • Trouble swallowing or speaking

  • Swelling of your face, lips, eyes, or tongue

  • Dizziness or fainting

  • Severe stomach cramps or pain, vomiting, or diarrhea

  • Hives (itchy, raised bumps on skin)

  • Severe flushing of the skin

WHAT IS PALFORZIA?

PALFORZIA is a treatment for people who are allergic to peanuts. PALFORZIA can help reduce the severity of allergic reactions, including anaphylaxis, that may occur with accidental exposure to peanut. PALFORZIA may be started in patients aged 4 through 17 years old. If you turn 18 years of age while on PALFORZIA treatment you should continue taking PALFORZIA unless otherwise instructed by your doctor.

PALFORZIA does NOT treat allergic reactions and should not be given during an allergic reaction.

You must maintain a strict peanut-free diet while taking PALFORZIA.

Because of the risk of severe allergic reactions, PALFORZIA is only available through a restricted program called the PALFORZIA Risk Evaluation and Mitigation Strategy (REMS) Program. Talk to your healthcare provider for more information about the PALFORZIA REMS program and how to enroll.

You should NOT take PALFORZIA if you have uncontrolled asthma, or if you ever had eosinophilic esophagitis (EoE) or other eosinophilic gastrointestinal disease.

Tell your doctor if you are not feeling well prior to starting treatment with PALFORZIA. Your doctor may decide to delay treatment until you are feeling better. Also tell your doctor about any medical conditions you have and if you are taking or have recently taken any other medicines, including medicines obtained without a prescription and herbal supplements.

Your doctor may decide that PALFORZIA is not the best treatment if:

  • You are unwilling or unable to receive (or self-administer) injectable epinephrine.

  • You have a condition or are taking a medication that reduces the ability to survive a severe allergic reaction.

What are the possible side effects of PALFORZIA?

The most commonly reported side effects of PALFORZIA were: stomach pain, vomiting, feeling sick, itching or burning in the mouth, throat irritation, cough, runny nose, sneezing, throat tightness, wheezing, shortness of breath, itchy skin, hives, and/or itchy ears.

PALFORZIA can cause severe allergic reactions called anaphylaxis that may be life-threatening.

PALFORZIA can cause stomach or gut symptoms including inflammation of the esophagus (called eosinophilic esophagitis). Symptoms of eosinophilic esophagitis can include:

  • Trouble swallowing

  • Food stuck in throat

  • Burning in chest, mouth, or throat

  • Vomiting

  • Regurgitation of undigested food

  • Feeling sick

For additional information on the possible side effects of PALFORZIA, talk with your doctor or pharmacist.

You are encouraged to report negative side effects of prescription drugs to the FDA. Visit www.fda.gov/medwatch, or call 1-800-FDA-1088.

Please see full Prescribing Information and Medication Guide, including an Important Warning about anaphylaxis.

WHAT IS PALFORZIA?

PALFORZIA is a treatment for people who are allergic to peanuts. PALFORZIA can help reduce the severity of allergic reactions, including anaphylaxis, that may occur with accidental exposure to peanut. PALFORZIA may be started in patients aged 4 through 17 years old. If you turn 18 years of age while on PALFORZIA treatment you should continue taking PALFORZIA unless otherwise instructed by your doctor.

PALFORZIA does NOT treat allergic reactions and should not be given during an allergic reaction.

You must maintain a strict peanut-free diet while taking PALFORZIA.

IMPORTANT SAFETY INFORMATION

PALFORZIA can cause severe allergic reactions called anaphylaxis that may be life-threatening.

  • You will receive your first dose in a healthcare setting under the observation of trained healthcare staff.

  • You will receive the first dose of all dose increases in a healthcare setting.

  • In the healthcare setting, you will be observed for at least 1 hour for signs and symptoms of a severe allergic reaction.

  • If you have a severe reaction during treatment, you will need to receive an injection of epinephrine immediately and get emergency medical help right away.

  • You will return to the healthcare setting for any trouble tolerating your home doses.

Stop taking PALFORZIA and get emergency medical treatment right away if you have any of the following symptoms after taking PALFORZIA:

  • Trouble breathing or wheezing

  • Chest discomfort or tightness

  • Throat tightness

  • Trouble swallowing or speaking

  • Swelling of your face, lips, eyes, or tongue

  • Dizziness or fainting

  • Severe stomach cramps or pain, vomiting, or diarrhea

  • Hives (itchy, raised bumps on skin)

  • Severe flushing of the skin

WHAT IS PALFORZIA?

PALFORZIA is a treatment for people who are allergic to peanuts. PALFORZIA can help reduce the severity of allergic reactions, including anaphylaxis, that may occur with accidental exposure to peanut. PALFORZIA may be started in patients aged 4 through 17 years old. If you turn 18 years of age while on PALFORZIA treatment you should continue taking PALFORZIA unless otherwise instructed by your doctor.

PALFORZIA does NOT treat allergic reactions and should not be given during an allergic reaction.

You must maintain a strict peanut-free diet while taking PALFORZIA.

Because of the risk of severe allergic reactions, PALFORZIA is only available through a restricted program called the PALFORZIA Risk Evaluation and Mitigation Strategy (REMS) Program. Talk to your healthcare provider for more information about the PALFORZIA REMS program and how to enroll.

You should NOT take PALFORZIA if you have uncontrolled asthma, or if you ever had eosinophilic esophagitis (EoE) or other eosinophilic gastrointestinal disease.

Tell your doctor if you are not feeling well prior to starting treatment with PALFORZIA. Your doctor may decide to delay treatment until you are feeling better. Also tell your doctor about any medical conditions you have and if you are taking or have recently taken any other medicines, including medicines obtained without a prescription and herbal supplements.

Your doctor may decide that PALFORZIA is not the best treatment if:

  • You are unwilling or unable to receive (or self-administer) injectable epinephrine.

  • You have a condition or are taking a medication that reduces the ability to survive a severe allergic reaction.

What are the possible side effects of PALFORZIA?

The most commonly reported side effects of PALFORZIA were: stomach pain, vomiting, feeling sick, itching or burning in the mouth, throat irritation, cough, runny nose, sneezing, throat tightness, wheezing, shortness of breath, itchy skin, hives, and/or itchy ears.

PALFORZIA can cause severe allergic reactions called anaphylaxis that may be life-threatening.

PALFORZIA can cause stomach or gut symptoms including inflammation of the esophagus (called eosinophilic esophagitis). Symptoms of eosinophilic esophagitis can include:

  • Trouble swallowing

  • Food stuck in throat

  • Burning in chest, mouth, or throat

  • Vomiting

  • Regurgitation of undigested food

  • Feeling sick

For additional information on the possible side effects of PALFORZIA, talk with your doctor or pharmacist.

You are encouraged to report negative side effects of prescription drugs to the FDA. Visit www.fda.gov/medwatch, or call 1-800-FDA-1088.

Please see full Prescribing Information and Medication Guide, including an Important Warning about anaphylaxis.

WHAT IS PALFORZIA?

PALFORZIA is a treatment for people who are allergic to peanuts. PALFORZIA can help reduce the severity of allergic reactions, including anaphylaxis, that may occur with accidental exposure to peanut. PALFORZIA may be started in patients aged 4 through 17 years old. If you turn 18 years of age while on PALFORZIA treatment you should continue taking PALFORZIA unless otherwise instructed by your doctor.

PALFORZIA does NOT treat allergic reactions and should not be given during an allergic reaction.

You must maintain a strict peanut-free diet while taking PALFORZIA.